
by Blockworks
139 episodes

Institutional adoption is accelerating the shift towards 24/7 financial markets built on blockchain technology. The most immediate and high-potential opportunity is the tokenization of U.S. Treasuries, which unlocks new efficiencies and round-the-clock trading. Established financial firm TradeWeb (TW) is a key public company to watch as it strategically builds an on-chain financing market for U.S. Treasuries. Expect a massive proliferation of new stablecoins over the next 12 to 18 months as more institutions compete in this growing market. Investors should focus on the "picks and shovels" infrastructure enabling this trend, while avoiding "wrapped" asset projects that lack institutional appeal.

Analysts are bullish on Bitcoin (BTC) as a core holding, viewing the recent dip as a buying opportunity and suggesting they would add to positions below $90,000. In contrast, they are extremely bearish on Ethereum (ETH), citing its massive overvaluation and fundamental flaws in capturing value from its own ecosystem. Investors should be cautious with the broader altcoin market, which is seen as a bubble, and instead focus on finding "killer apps" with real revenue and token buyback models. As a proxy investment for the promising Base ecosystem, consider buying stock in its parent company, Coinbase (COIN). Finally, look for opportunities outside of crypto, as speculative momentum has largely shifted to the AI sector.

Monitor the governance vote for Uniswap (UNI), as an approved proposal to activate its fee switch via a buyback and burn mechanism would be a significant bullish catalyst for the token. Consider the renewed momentum in Zcash (ZEC), which is experiencing a strong price increase and a revival in developer interest, making it risky to bet against. Investigate publicly traded companies like MasterCard (MA) and Coinbase (COIN) to gain exposure to the 'gold rush' in the stablecoin sector, which is seeing intense M&A activity. JPMorgan's use of the Base blockchain validates the 'corporate chain' trend, presenting a long-term bullish case for the Ethereum ecosystem. Given the market's bifurcation, be highly selective with altcoins, prioritizing projects with clear product-market fit over general hype.

Solana (SOL) is presented as the definitive winner for high-speed consumer applications, making it a high-conviction long-term investment. The upcoming integration of prediction markets into the Phantom wallet signals a major growth opportunity for leaders in the space like Polymarket and Kalshi. Phantom's new CASH stablecoin, built with Stripe, validates the successful revenue diversification model used by Coinbase (COIN) through its USDC partnership. The choice to integrate perpetual futures via Hyperliquid highlights that protocol's potential for significant user growth from a new mobile audience. Overall, the insights suggest prioritizing exposure to the Solana ecosystem over Ethereum (ETH) for consumer-focused growth themes.

For long-term investors, consider holding Coinbase (COIN) and Robinhood (HOOD), which are viewed as potential "generational assets" for the next 20 years. Another high-conviction theme is to invest in established public companies like Mercado Libre (MELI) and Nubank (NU) that are using blockchain technology to enhance their core businesses. For a value-oriented trade, Western Union (WU) is highlighted as a potential "mean reversion" play due to its very low valuation. It is recommended to view Bitcoin (BTC) as a distinct macro hedge, as it is considered a better long-term holding than most other crypto assets. Investors should be extremely cautious with most Layer 1 (L1) altcoins due to nonsensical valuations, with the suggestion to hold cash over lower-conviction positions.

The tokenization of Real-World Assets (RWAs) is a primary investment theme, with expectations that most financial instruments will be on-chain within five years. Canton Network, a privacy-focused blockchain, is a high-conviction infrastructure play designed to capture this institutional shift. The project is strongly validated by investments from financial giants like Goldman Sachs, Citadel, and the DTCC. Investors should monitor for a potential Canton token launch, which market speculation suggests could happen in 2025. This positions Canton as a key opportunity to invest in the convergence of traditional finance and blockchain.

The founder of Synthetix has taken a large, leveraged long position in SNX, signaling extreme personal conviction in the project's future. Consider a long-term position in Uniswap (UNI), as a potential governance change to activate a "fee switch" could significantly increase token value. Prepare for the upcoming Infinex token launch, expected within the next two to three months, which will feature token buybacks and user incentives. Investors should also monitor Polymarket for a potential future token launch or IPO, given its significant private market success. These opportunities are part of a broader investment theme in decentralized exchanges (DEXs) aiming to take market share from centralized platforms.

Consider Western Union (WU) as an undervalued turnaround play, as its new stablecoin partnership with Solana could be a major catalyst for the stock, which currently trades at a low 4.15x P/E ratio. For direct exposure to the growing tokenization of real-world assets, watch for Securitize, which is set to go public and could become the primary stock for this theme. Investors bullish on long-term technology trends like AI but seeking lower risk can gain broad exposure through a passive investment in the Invesco QQQ Trust (QQQ). The current crypto market is viewed as being in a 'rebirth' phase, potentially setting up a multi-decade bull market starting around 2025. Within this long-term trend, focus on crypto projects and companies that are generating real, on-chain revenue.

Galaxy Digital (GLXY.TO) is viewed as a strong long-term investment following a strategically brilliant capital raise that strengthens its balance sheet and funds future growth. Consider an investment in MicroStrategy (MSTR) as a catalyst trade ahead of its potential inclusion in the S&P 500 index in December, which could force billions in passive buying. For long-term crypto exposure, Solana (SOL) is presented as a superior fundamental holding to Ethereum (ETH) due to its stronger on-chain growth metrics. The broader AI and Tech stock theme remains bullish, supported by strong earnings, suggesting investors should remain allocated to risk for a potential "blow-off top." For those seeking exposure to the privacy narrative, Zcash (ZEC) is the primary asset to watch as it is attracting significant capital and attention.

Consider buying dips in Bitcoin (BTC), as market fear and selling by early investors are being absorbed by strong new demand from ETFs. For long-term growth, view Robinhood (HOOD) as a "picks and shovels" investment to gain exposure to the expansion of crypto and retail trading. When evaluating altcoins, focus on projects with real revenue that is returned to token holders, such as the online casino Shuffle (SHFL). The recent crash in Hyperliquid to the $35 level was highlighted as a strong re-entry point for those bullish on the project. A high-risk, time-sensitive trade is to consider shorting weak altcoins in late December to capitalize on predictable selling from tax-loss harvesting.

Monitor Coinbase ($COIN) to see if its strategic acquisition of crowdfunding platform Echo successfully drives new user growth and trading volume. The stablecoin theme is gaining significant institutional validation, with major companies like Stripe building their strategy around the technology. Stripe's aggressive push into stablecoins signals a major long-term disruption risk for traditional payment processors like Visa ($V) and Mastercard ($MA). This trend is further supported by potential Federal Reserve policy changes that could give stablecoin issuers direct access to payment systems, creating opportunities in the fintech sector. Conversely, investors should exercise extreme caution with deals on crowdfunding platforms due to the high risk of adverse selection.

Consider a long-term investment in Coinbase (COIN) as it expands beyond a simple exchange to become the core infrastructure for on-chain capital markets. The company is strategically positioning itself to lead the future tokenization of real-world assets, a multi-year secular growth trend. A significant near-term catalyst is the planned integration of prediction markets and sports betting into its platform, which is expected within the next 12 months. This feature is designed to attract a mainstream audience and could be a major driver of new user growth. Investing in COIN is a high-conviction way to gain exposure to the maturation of the digital asset ecosystem and its integration with traditional finance.

Consider focusing core crypto holdings in Bitcoin (BTC) and Ethereum (ETH), as these are the primary assets attracting long-term institutional investment. For exposure to decentralized finance, Aave (AAVE) is a standout blue-chip protocol that proved its resilience by performing flawlessly during the recent market crash. Solana (SOL) also demonstrated superior network performance under stress, making it a compelling high-throughput alternative to Ethereum. Exercise extreme caution with most altcoins, which showed a severe lack of liquidity and are being avoided by larger investors. Finally, avoid all leverage and be highly skeptical of most Digital Asset Trusts (DATs), as both have proven to be exceptionally risky.

Recent market volatility has reinforced the strategy of consolidating into high-quality assets while avoiding most illiquid altcoins. Solana (SOL) proved its network resilience under extreme stress, solidifying its position as a core holding alongside Bitcoin and Ethereum. A key emerging theme is the shift from centralized exchanges like Binance to more robust decentralized platforms, with Hyperliquid identified as a major winner. Hyperliquid is also poised for future growth with its upcoming support for real-world assets like the SPY and QQQ ETFs. Investors should exercise extreme caution with the broader altcoin market, as the recent crash revealed a dangerous lack of liquidity and high potential for catastrophic losses.

Prediction Markets are emerging as a massive, high-growth financial sector, with regulated platforms like Kalshi seeing explosive volume.
Consider Robinhood (HOOD) as a direct investment, as its new prediction markets feature is showing dramatic acceleration with over $2 billion in volume in Q3 alone.
This trend also reinforces the long-term investment case for Coinbase (COIN), which employs a similar regulation-first strategy to legitimize a new asset class.
A major upcoming catalyst for the digital asset space is the potential regulatory approval for stablecoins like USDC to be used directly in regulated U.S. clearinghouses.
Investors should monitor these companies as they are successfully integrating novel financial products for mainstream adoption.

Recent market volatility revealed that many large-cap altcoins have extremely fragile spot liquidity on major exchanges. This created a brief opportunity where top coins like Cosmos (ATOM), Aptos (APT), and Chainlink (LINK) flash-crashed by 80-90% before recovering. Investors can prepare for future volatility by placing low-ball limit buy orders on high-conviction altcoins to potentially acquire them at a deep discount. However, avoid using leverage on these assets, as the crash proved that even a 2x leveraged position could be easily liquidated. Be especially wary of perpetual futures platforms like Hyperliquid that use Auto-Deleveraging (ADL), which can forcibly close even profitable positions during a crisis.

Consider Binance Coin (BNB) as a trade on the narrative that its founder will return, a belief driving its recent outperformance against the market. The privacy coin sector appears to be re-emerging as a key theme, highlighted by Zcash (ZEC) recently surging over 300% in a single month. As the stablecoin market fragments, consider investing in infrastructure plays like Ethena (ENA) which enable other projects to launch their own stablecoins. To gain potential exposure to the highly-valued prediction market Polymarket, consider using its platform to potentially qualify for a speculative future POLY token airdrop. Finally, keep an eye on the upcoming Monad blockchain and its ecosystem projects like Purple for a future high-performance opportunity.

Atai Life Sciences (ATAI) is a high-conviction investment in psychedelic medicine, with the speaker believing it could become a $20-30 billion company by revolutionizing mental health treatment. As a "picks and shovels" play on the artificial intelligence boom, consider investing in the raw materials essential for its growth, such as Uranium and Copper. Maintain a long-term position in Bitcoin (BTC) as a primary hedge against the expected decline in value of traditional government-issued currencies. The core thesis connects these ideas, suggesting AI's societal disruption will increase the need for both mental health solutions from companies like ATAI and alternative assets like Bitcoin. Finally, consider long-term opportunities in the hospitality and live entertainment sectors, which are expected to grow as automation creates more leisure time.

The crypto market is expected to spike significantly over the next three to six months, suggesting the current cycle is far from its peak. Consider direct exposure to Solana (SOL), which is viewed as the most-used blockchain and is experiencing a strong resurgence in developer activity. The Base ecosystem is a key area to watch for emerging social and consumer-facing crypto applications, backed by its connection to Coinbase. Investors should also explore the Hyperliquid ecosystem, a leader in decentralized derivatives that is generating real revenue and performing like a centralized exchange. Finally, the rapid growth of stablecoins and on-chain yield products, like those in the **Ethena (

Consider Galaxy Digital (GLXY.TO) as a core long-term holding for diversified crypto and AI exposure, favored for its stable, contractual revenue. For a higher-risk opportunity, Pump.fun (PUMP) is presented as a top risk-return bet on the convergence of meme culture and crypto. The DePIN project Double Zero (00) is a notable infrastructure play, having received a bullish SEC 'no action letter' while already supporting over 10% of the Solana network. Be cautious with Hyperliquid (HYPE) due to intense competition and significant selling pressure expected from token unlocks around November. Finally, watch for new investment opportunities as ICOs and public token sales are returning, with launchpad platforms like Legion seeing high demand.