Invest Like the Best with Patrick O'Shaughnessy
Podcast

Invest Like the Best with Patrick O'Shaughnessy

by Colossus | Investing & Business Podcasts

33 episodes

Conversations with the best investors and business leaders in the world. We explore their ideas, methods, and stories to help you better invest your time and money. Hear stock market and boardroom insights you can't find anywhere else. If you're a professional investor, CEO, entrepreneur, or business strategist, this is for you. Explore all our episodes and learn more at https://www.joincolossus.com
Investment Summary
Updated 4 days ago
Summary of insights from content in the last 30 days

AI Infrastructure

Compute demands and power constraints are driving massive capital into specialized silicon, memory bottlenecks, and alternative energy sources ahead of the critical 2030 to 2032 bottleneck.

  • Memory shortage: MU, SK Hynix, and Samsung offer direct leverage to persistent High Bandwidth Memory and DRAM deficits.
  • Silicon alternatives: AMD provides a compelling value play as firms adopt cost-effective chip alternatives to premium NVDA pricing.
  • Foundry exposure: TSM remains an indispensable leader for advanced chip manufacturing alongside strategic plays like INTC.

Tech & Global Expansion

U.S. mega-cap platforms and strategic international tech leaders are capturing rapid structural scale, outperforming traditional tech generations.

  • Alphabet (GOOGL): Core mega-cap holding insulated from trade barriers and positioned for AI enterprise productivity gains.
  • Xiaomi (XIACF): Successfully expanding beyond consumer electronics to capture major market share in the high-performance EV sector.

AI-generated summary. Not investment advice. Learn more.

Ask about Invest Like the Best with Patrick O'ShaughnessyAnswers are grounded in this source's posts from the last 30 days.

Recent Posts

33 posts
Michael Moritz - Lessons From 40 Years of Investing and Writing - [Invest Like the Best, EP.491]

Investors should maintain long-term exposure to top-tier Artificial Intelligence (AI) and software leaders that are achieving massive scale and market dominance far faster than previous tech generations. Prioritize AI platforms driving broad productivity gains, focusing on long-term economic expansion rather than near-term labor disruption. Consider an investment in Xiaomi Corporation (1810.HK / XIACF) as the company successfully expands beyond consumer electronics to capture market share in the high-performance electric vehicle (EV) sector. Broaden your equity strategy to favor agile management teams with a proven track record of redeploying supply chain mastery and software expertise into large adjacent industries. Finally, for allocations in early-stage venture capital and private tech markets, direct capital toward exceptional founders who harness modern software tools for extreme operational leverage rather than traditional funds relying on disappearing information advantages.

Walter Russell Mead - How America Keeps Winning - [Invest Like the Best, EP.490]

Investors should maintain core exposure to U.S. Big Tech platforms like Alphabet Inc. (GOOGL), which are structurally insulated from physical trade barriers and positioned to drive productivity through artificial intelligence in enterprise and life sciences.

Within the defense sector, reallocate capital away from legacy heavy hardware toward software-driven defense technology, autonomous drones, and counter-drone systems built for modern, rapid-iteration warfare.

For international diversification, allocate to India as a leading long-term emerging markets play driven by demographic expansion and an accelerating domestic tech sector.

Real estate investors can capitalize on the ongoing shift to hybrid work by investing in suburban and exurban residential development and remote work infrastructure that expand traditional commuting zones.

Lastly, seek long-term exposure to frontier deep-tech leaders like SpaceX, OpenAI, and Anthropic, as computational and aerospace capabilities increasingly align with national strategic infrastructure.

Sarah Guo - What the 250 People Building AI Believe - [Invest Like the Best, EP.489]

Investors should build long-term positions in nuclear energy (specifically Small Modular Reactors) and natural gas infrastructure to solve data center power constraints ahead of the critical 2030 to 2032 bottleneck.

Reduce supply-chain risk by investing in domestic foundries and alternative specialized silicon accelerators to diversify away from single dependencies like Taiwan Semiconductor Manufacturing Company (TSMC).

Target computational biology and pharma AI platforms such as Chai Discovery, which are actively generating multi-million-dollar enterprise revenues by accelerating pharmaceutical drug discovery.

Prepare for near-term commercial breakthroughs in physical AI and semi-humanoid robotics by tracking innovators like Sunday Robotics ahead of consumer beta launches scheduled for late this year into early next year.

Allocate toward high-conviction vertical enterprise AI software, led by platforms like Harvey, that demonstrate strong enterprise pricing power by automating complex workflows in legal, accounting, and compliance sectors.

Neil Movva - Making AI 10x Cheaper - [Invest Like the Best, EP.488]

Investors should maintain core exposure to NVIDIA (NVDA) for premium real-time AI workloads and Taiwan Semiconductor Manufacturing Company (TSM) for indispensable advanced chip manufacturing leverage. Capitalize on critical hardware bottlenecks by investing in memory suppliers like Micron Technology (MU), SK Hynix, and Samsung, which stand to profit from persistent shortages in High Bandwidth Memory (HBM) and DRAM. Consider Advanced Micro Devices (AMD) as a compelling value play as major tech firms adopt cost-effective chip alternatives to diversify away from premium GPU pricing. Hold Intel Corporation (INTC) as a long-term strategic hedge against potential Asian semiconductor supply chain disruptions. Finally, expand into the emerging AI Inference Infrastructure and flexible power generation sectors as data center demand shifts toward low-cost, decentralized computing for background AI tasks.

Ben Thompson on Big Tech, China, and the AI Boom Running Out of Money - [Invest Like the Best, EP.487]

Invest in Alphabet (GOOGL) and Meta Platforms (META) for immediate, high-margin returns from AI-optimized advertising, complemented by Amazon (AMZN), which lowers cloud costs through custom silicon like Trainium.

Accumulate Intel (INTC) to capture upside from its foundry turnaround as Big Tech actively diversifies away from severe Taiwan Semiconductor Manufacturing Company (TSM) supply shortages projected to last through 2028–2029.

Hold Apple (AAPL) as a low-risk AI distribution play that captures high-margin software integration on consumer hardware without incurring heavy data center buildout costs.

Exercise caution with NVIDIA (NVDA), as long-term gross margins face compression from custom hyperscaler chips and deferred balance-sheet liabilities tied to compute buybacks through 2030.

Monitor Microsoft (MSFT) closely, as high computing costs and friction from usage-based pricing on enterprise tiers (such as the $100 per user per month E7 tier) may compress traditional software margins.

Eric Vishria - A Decade of Lessons Investing in Software & Hardware - [Invest Like the Best, EP.486]

Capitalize on the artificial intelligence boom by investing in market-leading hardware provider NVIDIA ($NVDA**), which powers the essential compute infrastructure for AI models. Look beyond pure AI software and invest in the dominant cloud oligopoly of Amazon Web Services ($AMZN), Microsoft Azure ($MSFT), and Google Cloud Platform ($GOOGL), as enterprise adoption accelerates. Take advantage of severe multiple compression in the Software-as-a-Service ($SaaS)** sector by selectively buying established enterprise software companies successfully pivoting to AI. Play the massive energy bottlenecks caused by surging data center demand by investing in power generation, electrical grid modernization, and nuclear energy infrastructure. Avoid zero-sum traps in emerging technologies and instead build a balanced portfolio across these interconnected semiconductor, cloud, software, and energy themes over the next 3 to 5 years.

Gavin Baker - AI Market Jitters - [Invest Like the Best, EP.485]

NVIDIA (NVDA) currently trades at its cheapest forward P/E multiple in a decade, presenting a prime long-term entry point for investors despite recent AI sector volatility. Underlying fundamentals for NVIDIA (NVDA) remain exceptionally strong as token growth and GPU rental pricing continue to accelerate rapidly. Investors should capitalize on short-term market panics to buy top-tier hardware and infrastructure providers like Microsoft (MSFT), Meta (META), and Amazon (AMZN), whose hyperscaler cash flows are surging. As older contracted compute bases expire, upcoming price re-adjustments will significantly drive revenue acceleration across the semiconductor sector.

Sam Altman - How to Make an Abundant Future - [Invest Like the Best, EP.484]

To capitalize on the booming artificial intelligence sector, focus your investments on foundational infrastructure providers rather than speculative application startups. Microsoft (MSFT) and **Oracle (ORCL) **remain top choices for capturing surging enterprise cloud demand and hosting large-scale AI operations. Meanwhile, NVIDIA (NVDA) sits at a critical supply chain bottleneck, providing the essential advanced hardware and GPUs required for all modern AI workloads. Investors should also target specialized chip designers and energy providers that drive crucial efficiency gains as data center power demands skyrocket. Always monitor potential risks related to permitting challenges and public pushback regarding the massive physical footprint of these new facilities.

Matthew Smith — How America Runs Out of Natural Gas by 2030 - [Invest Like the Best, EP.483]

Investors should prepare for a structural Natural Gas supply deficit starting in 2028, which could drive prices from the current $3.50 range to over $8.00 per MCF. Expand Energy (EXE) is a high-conviction play currently trading at a low 4x EBITDA, offering significant upside due to its control of critical Haynesville shale inventory. For exposure to the Appalachian region, EQT Corporation (EQT) and Range Resources (RRC) are top-tier producers positioned to benefit as gas becomes the primary fuel for U.S. power generation. To hedge against rising electricity costs, look toward utility-scale solar providers like NextEra Energy Partners (NEP) and Clearway Energy (CWEN), which can reprice power contracts at much higher margins. In the nuclear sector, Cameco (CCJ) and BWX Technologies (BWXT) are the strongest long-term bets to benefit from the necessary expansion of large-scale reactor infrastructure.

John Kim - How to Raise a Few Billion Dollars - [Invest Like the Best, EP.482]

Focus on high-growth infrastructure providers like WorkOS, Ramp, and Vanta, which are becoming essential for enterprise AI adoption and automated compliance. Monitor the Defense Tech sector closely, but prioritize firms with a long-term track record over those recently pivoting to the trend to avoid "diluted differentiation." When evaluating new ventures like Lila Sciences, apply the Persuasion Equation by ensuring the team has a clear plan to mitigate risk while driving high desire through "scientific superintelligence." Look for investment opportunities that exhibit true Scarcity, similar to the Benchmark model, as these assets move capital the fastest and maintain the best terms. Prioritize companies with a simple, defensible value proposition, as high Complexity in a business story often signals a lack of reliability and slows down institutional support.

Jeremy Giffon - The Billion Dollar PDF - [Invest Like the Best, EP.481]

Investors should target "Old" Private Companies (6–7 years old) that have recently inflected due to AI catalysts, as their slow starts often lead to significant undervaluation compared to newer startups. Avoid traditional SaaS companies with per-seat pricing models and instead prioritize AI-native software firms that utilize usage-based pricing to offset higher compute costs. For private market exposure, prioritize Emerging Managers over large growth funds, as smaller managers are more psychologically and financially aligned with generating high returns rather than collecting fees. Retail investors should exploit their lack of "career risk" by holding high-conviction, "weird" assets like Bitcoin or "Long Elon" plays (Tesla, SpaceX secondary markets) that institutional mandates often restrict. Monitor X (formerly Twitter) as a leading indicator for market sentiment, as algorithmic narratives now drive high-variance pricing in the Mag 7 and broader tech sectors.

Etched - Building AI Hardware to Make Inference Faster and Cheaper - [Invest Like the Best, EP.480]

The shift from AI training to inference (running models) is creating a massive opportunity for specialized hardware that outperforms general-purpose GPUs. Investors should look toward TSMC (TSM), which remains the essential manufacturing partner for next-generation AI chips like those from Etched and big-tech hyperscalers. While NVIDIA (NVDA) remains the industry benchmark, its high margins are under threat from application-specific chips (ASICs) designed to run "Transformer" architectures more efficiently. Consider exposure to the "Token Economy" by focusing on companies that maximize "tokens per watt," as energy availability is now the primary bottleneck for AI scaling. By 2027, the market is expected to pivot from "per-seat" software pricing to "per-inference" costs, benefiting high-growth AI agent platforms like Perplexity and Anthropic.

Vlad Barbalat - Investing $120 Billion in Permanent Capital - [Invest Like the Best, EP.479]

Investors should prioritize US-based assets over international markets, leveraging the country's energy abundance and "permissionless innovation" as a structural advantage. Focus on Asset-Backed Finance and Direct Lending as high-conviction alternatives to traditional bond portfolios to capture yield in a shifting credit environment. Consider reducing long-term exposure to legacy software giants like Salesforce (CRM) and Oracle (ORCL), as AI-native competitors threaten their 30-year terminal value. Allocate capital toward Data Center Infrastructure and Energy projects, which are essential to supporting the massive physical requirements of the AI revolution. Maintain a "just-in-case" investment posture by favoring private equity and infrastructure over public markets to avoid short-term volatility and quarterly earnings pressure.

Kareem Amin - Re-Enchanting the World - [Invest Like the Best, EP.478]

Investors should prioritize usage-based SaaS platforms like Clay that replace traditional per-seat pricing with value-driven models, aligning perfectly with AI-driven productivity gains. Focus on "picks and shovels" infrastructure providers like Vanta and WorkOS, which capture value by enabling AI startups to meet essential enterprise security and compliance standards. In the financial sector, look for unified platforms like Ridgeline and AI-agent tools like Rogo that consolidate fragmented data and automate complex investment banking workflows. High-conviction opportunities lie in tools that democratize "computation," allowing non-technical teams in marketing and operations to build custom automated systems without engineers. When evaluating founders, favor those practicing "long-term greed" by prioritizing high integrity and reputation over short-term gains, as these leaders are best positioned to navigate genuine market risk.

Alex Sacerdote - How to Invest Through Technology Cycles - [Invest Like the Best, EP.477]

Investors should prioritize NVIDIA (NVDA) as the essential infrastructure play, as its specialized chips remain the primary beneficiary of a "tornado of demand" that continues to exceed market earnings models. For foundational AI exposure, Google (GOOGL) is a high-conviction pick due to its technical superiority in document processing and its guaranteed spot in the emerging three-player model oligopoly. Look for "de-commoditized" hardware winners like Celestica (CLS) for its 60% share in AI Ethernet switches and Corning (GLW) for the massive fiber optic demand required to connect data centers. While Anthropic is the top private conviction for its $500 billion coding market opportunity, public investors should pivot away from traditional SaaS stocks like Salesforce (CRM), which face severe budget cannibalization from AI. We are currently at only 0.1% penetration of AI adoption, suggesting significant upside remains for companies where average selling prices are rising due to increased manufacturing complexity.

Dara Khosrowshahi - Uber's Bet on AVs, AI, and Building a Super-App - [Invest Like the Best, EP.476]

Investors should consider Uber (UBER) as a primary play in the "physical AI" space, as the company leverages over $10 billion in free cash flow to dominate the autonomous vehicle (AV) market. Monitor Uber One membership growth, currently at 50 million members, as this recurring revenue stream is expected to drive high-margin, long-term profitability. Look for Uber to act as the essential go-to-market partner for AV firms like Waymo, Lucid, and Aurora, benefiting from a 30% higher utilization rate than standalone networks. In the broader robotics sector, expect delivery drones to reach commercial scale within the next 2 to 5 years, significantly reducing delivery times for food and groceries. For enterprise exposure, focus on infrastructure providers like WorkOS and Vanta that enable AI leaders like OpenAI and Anthropic to scale security and compliance.

Dan Loeb - Lessons from 30 Years of Investing - [Invest Like the Best, EP.475]

NVIDIA (NVDA) remains a high-conviction "catch-up trade" with attractive valuation multiples of 15x 2027 earnings, making it a core play for the multi-year AI expansion. Investors should look to build positions in Danaher (DHR) during market sell-offs, capitalizing on its superior operational system as COVID-related inventory distortions fade. In the credit markets, X debt offers a high-conviction 12% yield for those comfortable with the underlying enterprise value of the platform. Sony (SONY) presents a significant "governance alpha" opportunity as Japanese regulatory shifts and activist pressure force the company to spin off non-core assets and unlock shareholder value. To capture the full AI Stack, diversify across Semiconductors, Semi-cap equipment, and Hyperscalers, while monitoring Anthropic's growth as a primary indicator of ecosystem health.

Darren Farber on Iran, China, and the Rise of Neoprimes - [Invest Like the Best, EP.474]

Investors should pivot toward "Neoprimes" that bridge commercial technology with military applications, specifically focusing on drones, signals intelligence, and automated targeting software. Monitor the KMT party in Taiwan, as their political success could signal a peaceful regional power shift that reduces the immediate risk of a kinetic conflict with China. High-conviction opportunities exist in AI firms like OpenAI, Anthropic, and Perplexity, but priority should be given to companies that can verify data provenance to prevent "data poisoning" by adversaries. For enterprise infrastructure, look to specialized service providers like WorkOS, Vanta, and Ridgeline that facilitate security and compliance for high-growth tech sectors. Be cautious of small defense-tech firms during Congressional "Continuing Resolutions," as these budget delays pose significant liquidity risks compared to legacy defense giants.

Gavin Baker - Watts and Wafers - [Invest Like the Best, EP.473]

Investors should maintain core exposure to NVIDIA (NVDA), which remains historically undervalued relative to its growth as the primary "seller of shortage" in the AI supply chain. Taiwan Semiconductor (TSM) acts as the critical gatekeeper for the industry; as long as they maintain high utilization without overbuilding capacity, the structural floor for AI valuations remains intact. High Bandwidth Memory (HBM) providers like Micron (MU) and SK Hynix offer a compelling valuation play as memory shifts from a commodity to a high-value AI component with extended hardware lifecycles. For software exposure, prioritize companies in the "token path" like Databricks or Snowflake, and favor Anthropic over competitors due to its superior capital efficiency and massive revenue scaling. Finally, monitor the U.S. energy sector and Natural Gas (NG1), as domestic power advantages provide a significant competitive moat for American AI data centers through 2027.

Krishna Rao - Anthropic's CFO on Compute, Scaling to $30B ARR, and the Returns to Frontier Intelligence - [Invest Like the Best, EP.471]

Investors should prioritize Amazon (AMZN) and Google (GOOGL) as they secure long-term revenue moats through multi-billion dollar compute commitments from Anthropic. While NVIDIA (NVDA) remains a core holding, Anthropic’s successful use of Trainium and TPU chips suggests a growing trend of hardware diversification that reduces single-vendor dependency. For exposure to the "Enterprise-Ready" bottleneck, look toward private infrastructure leaders like WorkOS and Vanta which enable AI startups to meet the security standards of the Fortune 500. Specialized "Vertical AI" agents like Rogo are high-conviction plays for disrupting specific industries like financial services by automating complex Excel and PowerPoint workflows. The most significant growth opportunity lies in the $40 trillion global knowledge work market as AI shifts from simple chat interfaces to autonomous "Virtual Collaborators" with internal company memory.

Top assets covered by Invest Like the Best with Patrick O'Shaughnessy

The 12 most-discussed assets across Invest Like the Best with Patrick O'Shaughnessy’s content on Kazuha (out of 104 total).

Invest Like the Best with Patrick O'Shaughnessy’s sentiment — last 30 days

Aggregate of all sentiment-scored insights from Invest Like the Best with Patrick O'Shaughnessy in the last 30 days.

Strongly bullish
avg +0.54
10 bullish0 neutral1 bearish

Frequently asked about Invest Like the Best with Patrick O'Shaughnessy

What does Invest Like the Best with Patrick O'Shaughnessy talk about on Kazuha?

Kazuha indexes 33 posts from Invest Like the Best with Patrick O'Shaughnessy, with AI-extracted insights covering 104 distinct assets (stocks, ETFs, cryptocurrencies, and other investable assets).

Which assets does Invest Like the Best with Patrick O'Shaughnessy cover the most?

Invest Like the Best with Patrick O'Shaughnessy's most-discussed assets on Kazuha are NVDA, GOOGL, MSFT, TSM, SNOW. See the "Top assets covered" section above for the full breakdown with sentiment.

Is Invest Like the Best with Patrick O'Shaughnessy bullish or bearish right now?

Mostly bullish. In the last 30 days, Invest Like the Best with Patrick O'Shaughnessy had 10 bullish, 1 bearish, and 0 neutral takes across all assets they discussed (per AI-extracted sentiment scoring on Kazuha).

Where does Kazuha get Invest Like the Best with Patrick O'Shaughnessy's insights?

Invest Like the Best with Patrick O'Shaughnessy's publicly available content (podcast episodes, YouTube videos, or X/Twitter posts) is transcribed and analyzed by an LLM that extracts the assets discussed and the speaker's sentiment toward each one. Each insight links back to the original source.