
by John Coogan & Jordi Hays
338 episodes

Amazon (AMZN) is a high-conviction play as it shifts toward aggressive capital expenditure to double its power capacity by 2027 and scale its custom Graviton and Trainium silicon. Investors should watch the healthcare segment as Amazon Pharmacy scales same-day delivery for Eli Lilly’s new GLP-1 pill, Foundayo, creating a major new retail growth lever. Bitcoin (BTC) remains a core portfolio stabilizer as more corporations adopt "mini-MicroStrategy" treasury models, providing a resilient price floor despite geopolitical volatility. The next phase of the AI trade is shifting from chips to energy infrastructure and nuclear power, as grid capacity becomes the primary bottleneck for data center expansion. For specialized growth, look toward Xona Space, which is building a private satellite constellation to provide centimeter-level navigation accuracy essential for the future of autonomous robotics and vehicles.

Meta Platforms (META) is a strong buy-and-hold as it shifts from open-source to a closed-source AI model with MuseSpark, a move designed to slash operational costs and improve profit margins. Investors should maintain exposure to NVIDIA (NVDA), as the successful scaling of models like Anthropic’s Mythos on Blackwell architecture confirms that the multi-year demand for high-end hardware remains unsaturated. The launch of Mythos serves as a major catalyst for the cybersecurity sector; look to CrowdStrike (CRWD) and Palo Alto Networks (PANW) as they gain exclusive early access to these frontier "bug-hunting" tools. For those seeking defensive growth, Lockheed Martin (LMT) represents a strategic play on the increasing intersection of AI, quantum sensors, and national security. The broader "compute war" favors "Big Tech" firms with the massive capital required to train 10-trillion parameter models, effectively creating a high-barrier moat against smaller competitors.

Buy Meta Platforms (META) as it shifts to a high-margin "profit phase" with its new closed-source MuseSpark model, which offers frontier-level performance at a fraction of the compute cost. Maintain core exposure to NVIDIA (NVDA) to capture the ongoing infrastructure supercycle, as massive demand for Blackwell architecture from tech giants continues to drive a potential multi-trillion dollar valuation. Increase allocations to cybersecurity leaders CrowdStrike (CRWD) and Palo Alto Networks (PANW), which are becoming essential "board-level" priorities to defend against AI-powered supply chain attacks. Monitor the industrial tech and defense sectors for "reshoring" opportunities, specifically looking for future IPOs from "hard tech" companies like SpaceX or Cerebras. For speculative growth, watch for private market valuations to rise in Anthropic and prediction platforms like Kalshi as they establish themselves as dominant "sources of truth" and critical infrastructure partners.

Investors should consider Meta Platforms (META) as a long-term vertical integration play, as the company’s aggressive internal AI usage justifies building proprietary models that could save billions in third-party licensing fees. Intel (INTC) is a high-conviction turnaround candidate following its partnership with Tesla and SpaceX, positioning it as the primary domestic foundry alternative to TSMC for high-performance AI chips. While Anthropic remains private, its $30 billion revenue run-rate and new cybersecurity model, Mythos, signal a massive enterprise shift that benefits its infrastructure partners like Google (GOOGL) and Broadcom (AVGO). The emerging "Space-Based Compute" sector, led by Starlink technology, offers a niche opportunity for investors to scout companies specializing in space-hardened hardware and satellite cooling systems. Monitor the "Token Economy" shift, where corporate budgets are expected to pivot from traditional headcount toward a $250,000 annual AI token spend per engineer.

The safest and most immediate way to play the AI cycle is through the infrastructure layer, specifically high-conviction semiconductor and manufacturing leaders like NVIDIA (NVDA) and TSMC (TSM). Investors should prioritize companies with immense pricing power and ecosystem lock-in, such as Apple (AAPL), which has proven it can defy traditional electronics deflation by consistently increasing its average revenue per user. Monitor the "Founder Mode" trend in companies like Workday (WDAY) and Block (SQ), as firms led by their original founders are often better positioned to execute the radical pivots required by the AI era. For long-term growth, watch for the eventual public offerings of private AI leaders like OpenAI, Anthropic, and Cerebras, which are currently defining the next generation of data-heavy architecture. Before committing capital, ensure your investment thesis is simple enough to explain in three sentences and is backed by a financial model that reflects a clear narrative rather than just following bank estimates.


Avoid high-risk telehealth providers like Medvi that rely on aggressive marketing and compounded GLP-1 drugs, as regulatory crackdowns and "misbranding" warnings from the FDA threaten their long-term valuation. Conversely, the success of the game Balatro highlights a massive opportunity in solo-developed, AI-assisted gaming IP, which can generate near 100% profit margins and high acquisition interest. Investors should maintain a bearish outlook on the Chinese Pork Industry due to a structural oversupply caused by "swine scraper" high-rises and a consumer shift toward healthier proteins. In the defense sector, focus on companies developing cheap counter-drone technology, as the Pentagon shifts its budget toward low-cost, mass-produced hardware like the LUCAS drone. Finally, while Apple (AAPL) is seeing a surge in App Store submissions due to AI, the real value lies in identifying the first "AI-native" viral app rather than the influx of low-quality, single-use software.

Investors should exercise extreme caution with MedV and the GLP-1 telehealth sector due to thin 15% margins, aggressive marketing tactics, and looming FDA regulatory scrutiny. In the AI space, monitor OpenAI for a potential IPO as early as Q4 2026, but be aware of their massive projected $121 billion compute spend through 2028. Anthropic’s acquisition of Coefficient Bio signals a high-conviction shift toward AI drug discovery, making biotech a primary value unlock for large language models. Within the defense sector, look for opportunities in "low-cost attritable systems" like the Lucas (FLM 136) drone, as the Pentagon shifts procurement toward cheaper, mass-produced autonomous weapons. Finally, the B2B stablecoin market is a high-growth area for 2025, with infrastructure providers like Better Money and Stripe benefiting from new regulatory clarity for instant corporate payouts.

Investors should prioritize companies utilizing AI-driven corporate downsizing to expand margins, specifically monitoring Pinterest (PINS) and Block (SQ) as they cut headcount to improve efficiency. The GLP-1 weight loss sector remains a high-conviction play; look for "lean" telehealth startups that use AI to automate distribution and customer acquisition at scale. While OpenAI remains private, its acquisition of TBPN signals a shift toward direct media ownership, suggesting that public AI leaders will increasingly invest in content infrastructure to drive regulatory and public "buy-in." In the space sector, SpaceX continues to normalize orbital flight, while Omega (part of The Swatch Group) maintains a dominant branding position through its mission-critical hardware. For private market exposure, focus on "one-person billion-dollar" models like Medvi, which are achieving massive revenue-per-employee ratios by replacing traditional departments with AI tools.

Investors should monitor Hims & Hers (HIMS) as a public benchmark for the hyper-efficient GLP-1 market, where AI-driven "solopreneur" startups are now achieving billion-dollar scales with minimal overhead. NVIDIA (NVDA) remains a high-conviction play as it expands into space-based infrastructure, partnering with StarCloud to develop radiation-hardened chips for orbital data centers. In the cybersecurity sector, CrowdStrike (CRWD) is a critical holding as the industry pivot shifts focus from device security to identity-based protection against sophisticated supply chain attacks. For those interested in the "agentic economy," Circle’s USDC is emerging as the dominant protocol for autonomous AI-to-AI payments, offering a 24-month growth window for programmable finance. Finally, watch for the 2026 launch of Wonder Create, which aims to disrupt the traditional franchising model by allowing users to launch restaurant brands via AI for just $10 a month.

Monitor SpaceX closely for a potential IPO filing, as a public listing would create a trillion-dollar "generational event" and provide a massive catalyst for the broader Space and Defense sector. Follow the "Combs Notepad" by investing in domestic "hard tech" and reindustrialization plays like Shield AI and Perpetual Resources, which are backed by JPMorgan’s (JPM) new $10 billion strategic fund. Consider a speculative position in Snap Inc. (SNAP) as activist pressure from Irenic Capital targets a $26 price objective through aggressive cost-cutting and AI-driven ad improvements. Position for the maturing "Lunar Economy" by identifying secondary plays in satellite communications and space-based data centers that benefit from rapidly declining launch costs. Focus long-term capital on the Security and Resiliency sector, where private investment is shifting toward U.S. semiconductors, aerospace, and energy independence.

Investors should view Apple (AAPL) as a vertically integrated services powerhouse rather than just a hardware manufacturer, as its high-margin services division continues to drive ecosystem lock-in. A major near-term catalyst is Apple’s aggressive expansion into live sports, specifically Formula 1, which is significantly boosting U.S. viewership and engagement through tech-enhanced features like "multi-view." This partnership provides a strong tailwind for Formula One Group (FWONA / FWONK), making it a primary beneficiary of Apple’s massive media reach and marketing spend. For those looking at emerging tech, the Vision Pro is carving out a high-end niche in "Sim Racing" and immersive gaming, signaling the next phase of hardware-software synergy. Monitor Apple’s ability to outbid traditional media for sports rights, as this remains the critical factor for sustaining the growth of Apple TV+ and its subscription revenue.

Investors should monitor Snap Inc. (SNAP) as activist pressure from Irenic Capital targets a $26 price objective through aggressive cost-cutting and improved AI ad monetization. JPMorgan Chase (JPM) is pivoting toward a "re-industrialization" strategy, making it a core play for those betting on U.S. domestic manufacturing, defense tech, and small business growth. The massive energy requirements for AI data centers make Microsoft (MSFT) and Chevron (CVX) primary partners in the natural gas space, while Redwire Space (RDW) offers niche exposure to the growing lunar economy. Apple (AAPL) remains a high-conviction long-term hold as it leverages sports content and the Vision Pro to transition further into a high-margin services powerhouse. Keep a close watch for a potential SpaceX IPO, which would serve as a generational catalyst for the entire aerospace and satellite sector.

Investors should prioritize Cybersecurity firms and automated scanning providers like CrowdStrike (CRWD) or Palo Alto Networks (PANW) as supply chain attacks on critical infrastructure like Axios become more frequent. Developers and tech firms must immediately pin Axios versions to 1.14.0 and rotate all API keys to mitigate recent malware risks. With Google (GOOGL) targeting 2029 for quantum migration, consider hedging Bitcoin (BTC) exposure with Quantum Computing stocks like IonQ (IONQ) or Rigetti (RGTI) which often rally on breakthrough encryption news. In the entertainment sector, look for "shovels" in the AI video space and monitor traditional media giants like Disney (DIS) or Warner Bros (WBD) to see if they successfully monetize AI-driven community remixes of their IP. Finally, the "recursive AI" trend at Anthropic suggests a massive productivity tailwind for software companies that successfully integrate AI agents into their own development pipelines.

Investors should prioritize Google (GOOGL) as it accelerates AI product velocity through DeepMind and leads the critical 2029 transition to post-quantum security. Monitor Bitcoin (BTC) and Ethereum (ETH) for "hard fork" upgrades to post-quantum cryptography, as solving this "quantum discount" could trigger a significant price re-rating. In the private markets or via specialized ETFs, look for exposure to "Physical AI" through companies like Applied Intuition, which solves labor shortages in mining and agriculture. The rise of AI-generated code increases the risk of supply chain hacks, making automated cybersecurity firms like CrowdStrike (CRWD) essential long-term holdings. Finally, consider the "longevity" trend by following Whoop’s expansion into medical-grade health monitoring and Public.com’s new autonomous AI agents for retail yield optimization.

Investors should consider NVIDIA (NVDA) a high-conviction play as the company secures massive government contracts for its Blackwell architecture, including a 110,000-GPU supercomputer project with Oracle (ORCL). For high-risk seekers, Fannie Mae (FNMA) and Freddie Mac (FMCC) offer potential "10X" upside if the U.S. government ends their conservatorship, though these remain speculative political plays. Monitor Meta (META) and Alphabet (GOOGL) closely, as recent legal defeats regarding "addictive" product design create existential risks to their long-term advertising revenue and engagement models. To gain exposure to the emerging "Physical AI" robotics sector, retail investors can use Amazon (AMZN) and Alphabet (GOOGL) as proxies while the leader, Physical Intelligence, remains private. Finally, watch for a sentiment boost in the Aerospace and Defense sector as the Artemis II moon mission nears its projected early 2025 launch window.

Investors should view the current 21% drawdown in NVIDIA (NVDA) as a high-conviction buying opportunity, as fundamental demand for AI inference and new Blackwell chip orders in China remain robust. Meta Platforms (META) is a resilient play for those looking to capitalize on AI-enhanced advertising, with massive capital expenditures expected to drive significant returns by 2028. To capture the shift toward AI "agents" that require heavy orchestration, investors should look at ARM Holdings (ARM) and AMD as the demand for high-performance CPU cores is projected to quadruple. Monitor Intel (INTC) and Samsung as potential beneficiaries of manufacturing overflows if TSMC reaches maximum capacity for high-end AI chips. While the sector remains strong, keep a 6-month watch on geopolitical tensions in the Middle East, as a prolonged conflict could trigger a critical helium shortage necessary for semiconductor production.

The current NVIDIA (NVDA) drawdown presents a high-conviction buying opportunity as skyrocketing demand for AI inference and the upcoming 2026 Blackwell GPU launch drive long-term growth. Investors seeking asymmetric returns should look at Fannie Mae (FNMA) and Freddie Mac (FMCC), which trade at a fraction of their annual income and could see a 10x return if privatized. While Meta Platforms (META) remains fundamentally cheap, be cautious of mounting legal liabilities regarding "addictive features" that could lead to multi-billion dollar class-action settlements. Alphabet (GOOGL) faces significant headwinds as AI chatbots threaten its core search revenue and TSMC (TSM) capacity constraints limit its hardware production. For long-term exposure to the "Humanoid" era, monitor the robotics software layer, specifically private firms like Physical Intelligence, which aims to become the operating system for future home and industrial robots.

Investors should consider Novartis (NVS) as a defensive play, as the company is aggressively acquiring biotech assets like Excellergy to offset upcoming patent cliffs for its blockbuster drugs. Keep a close watch on Anthropic for a potential $60 billion IPO by late 2026, a move that would likely serve as a major bullish catalyst for NVIDIA (NVDA) due to increased GPU demand. Business owners should prepare for OpenAI’s self-serve advertising platform launch in April 2026 to capture early-adopter advantages in a high-margin digital ad space. Apple (AAPL) is shifting its "walled garden" strategy by opening Siri to third-party AI, creating a new monetization stream through App Store commissions on AI subscriptions. For broader exposure to efficiency gains, look toward Novo Nordisk (NVO) and other "Big Pharma" firms using AI to drastically reduce the time and cost of clinical trials and FDA filings.

Retail investors can now gain liquid exposure to high-growth private "unicorns" like OpenAI and Anthropic by purchasing the Fundrise (VCX) fund, which recently listed on the NYSE. Keep a close watch on Anthropic for a potential $60 billion IPO as early as Q4 2026, as it currently leads the race for a major public AI offering. In the biotech sector, monitor Novartis (NVS) as it aggressively acquires startups like Accelergy to bolster its pipeline against expiring patents. The defense sector is shifting toward "National Interest" technology, making autonomous software firms like Shield AI critical players in the transition from hardware to AI-driven defense. For long-term semiconductor exposure, look beyond general GPUs toward companies developing custom ASICs and energy-efficient chips to solve the looming power shortfall predicted for 2028.