
Investors should prioritize OpenAI and Anthropic as they dominate the high-end reasoning market, but watch for OpenAI’s upcoming Jalapeno chip (developed with Broadcom) to potentially slash inference costs by 50%. Avoid legacy consulting firms like Accenture (ACN) and seat-based software providers like Salesforce (CRM), as AI agents are rapidly destroying their traditional moats and manual billing models. Monitor NVIDIA (NVDA) and the semiconductor sector closely, as a 90% surge in DRAM costs signals a "100-year flood" of hardware inflation that will likely force Apple (AAPL) to raise consumer prices. Be cautious with Google (GOOGL); despite its scale, it faces significant "number three" risk and a talent drain to more agile competitors. For a high-growth alternative, watch for a potential Kalshi IPO as prediction markets hit a $2 billion run rate, though Meta (META) remains a looming threat if they enter the social betting space.

By Harry Stebbings
The Twenty Minute VC (20VC) interviews the world's greatest venture capitalists with prior guests including Sequoia's Doug Leone and Benchmark's Bill Gurley. Once per week, 20VC Host, Harry Stebbings is also joined by one of the great founders of our time with prior founder episodes from Spotify's Daniel Ek, Linkedin's Reid Hoffman, and Snowflake's Frank Slootman. If you would like to see more of The Twenty Minute VC (20VC), head to www.20vc.com for more information on the podcast, show notes, resources and more.