Galaxy Digital Holdings ($GLXY) is poised for significant upside due to a shift in U.S. crypto regulatory sentiment, which is seen as a major tailwind. This positive change, highlighted by Bitwise CIO Matt Hougan, is believed to be "not priced in" by the market, suggesting potential for GLXY and other crypto-related assets like Ethereum, Solana, and Uniswap to move on a faster timeline. The improved regulatory environment could facilitate GLXY's long-awaited NASDAQ uplisting, further boosting its valuation.