Why AI Agents Can Beat the Incumbents
Why AI Agents Can Beat the Incumbents
Podcast59 min 48 sec
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Note: AI-generated summary based on third-party content. Not financial advice. Read more.
Quick Insights
  • Prioritize the vertical AI theme, especially procurement automation, but favor companies that demonstrate reliable end-to-end execution, handle exceptions, and deliver measurable customer savings—not just impressive demos.
  • Treat Leo as a private-company example of this opportunity, not an available investment based on the information provided; monitor production adoption, customer value, and how much human review its agents still require.
  • The discussion offers no actionable stock call, price target, or timeframe for CRM, SAP, or ORCL; evaluate incumbents’ distribution advantages against focused AI firms’ ability to automate workflows across systems.
Detailed Analysis

Enterprise vertical AI and procurement automation

  • The central investment opportunity discussed is vertical AI: agents that take responsibility for an entire business task rather than simply retrieving information or adding a chatbot to existing software.
  • Procurement is presented as a promising use case because much of the work happens outside systems of record—in emails, spreadsheets, contracts, engineering files, and conversations—and often requires coordination across procurement, finance, legal, and engineering.
  • The potential value comes from handling exceptions and making decisions, not just automating routine steps. The speakers cited missed supplier-delay emails as an example of a small oversight that could delay a project and cause hundreds of millions of dollars in damage.
  • The discussion also emphasizes potential operating benefits: negotiating purchases that companies previously lacked capacity to negotiate, reducing friction, and improving project timing. One speaker said that, in their framing, a 1% procurement savings could have a P&L impact comparable to generating 10% more sales.
  • Actionable takeaway: When evaluating this theme, look for products that can reliably complete multi-step work across systems and handle exceptions—not merely demonstrate an impressive chatbot or prototype.
    • The speakers identified meaningful hurdles: poor-quality or fragmented company context, complex integrations and custom workflows, and the fact that performance that is not sufficiently accurate may still leave humans doing all the work.
    • Trust is also a constraint. The discussion describes gradual adoption, with human review used to build confidence before agents take on more autonomous or higher-stakes tasks.
  • No public-market recommendations, price targets, or investment timelines were given.

Leo (private company; no ticker)

  • Leo builds AI agents for enterprise procurement, including sourcing, invoice exceptions, supplier communications, and negotiations.
  • The company’s approach is to coordinate agents across the workflow, with the level of autonomy varying according to the task’s risk and complexity.
  • The CEO said Leo can handle some purchases autonomously, while complex, multi-million-dollar negotiations retain expert humans in the loop. Human feedback also helps train and evaluate the agents and build customer trust.
  • Leo’s longer-term opportunity, as described in the episode, is to support work between buyers and suppliers—not just automate tasks inside one company. The speakers suggested that agents on both sides could reduce friction on shared tasks, even when the parties have conflicting interests over price.
  • Actionable takeaway: Leo is a case study in the vertical-AI thesis, but the transcript provides no financial results, valuation, or evidence of investment availability. For investors assessing similar companies, relevant indicators would include measurable customer value, increasing automation in production, and the ability to handle exceptions without creating additional review work.
    • The discussion specifically flags trust, accuracy, implementation complexity, and the need for human oversight in sensitive negotiations as challenges.

Salesforce (CRM)

  • Salesforce is discussed as an incumbent with meaningful customer trust and distribution. Its Agentforce product was given as an example of an agent that customers may readily try, particularly when it is easy to activate or offered at little extra cost.
  • The speakers said incumbent offerings have generally started with information retrieval and simple processes, while more judgment-intensive, end-to-end work can be harder to pursue. They cited potential internal conflicts between selling workflow software and selling software that resolves the work itself.
  • Actionable takeaway: The episode presents a competitive question, not a bullish or bearish stock call: incumbents may benefit from distribution, while focused startups may have room to own workflows that span multiple systems and departments. The transcript gives no Salesforce price target or stock recommendation.

SAP (SAP), Oracle (ORCL), and Coupa (private)

  • SAP and Oracle are mentioned as enterprise systems that procurement agents can update or work alongside. The speakers’ point is that the system of record may show a final price or delivery date while omitting the emails, analysis, and exceptions behind it.
  • Coupa is mentioned as an example of a legacy procurement system. The episode argues that many procurement tools have made established processes more efficient without fundamentally changing how people work.
  • Actionable takeaway: The discussion suggests that systems of record may remain important infrastructure even if new AI applications take on more of the work around them. It does not provide a company-specific outlook, price target, or recommendation for SAP, Oracle, or Coupa.

OpenAI and Anthropic

  • OpenAI and Anthropic are mentioned as model providers that incumbents may partner with. Leo’s CEO said the company uses models from multiple providers and views general-purpose models as a commodity for some tasks.
  • The proposed source of differentiation is the surrounding product: integrations, workflows, evaluation processes, proprietary or industry-specific data, and the ability to deliver a reliable business outcome.
  • Actionable takeaway: The discussion favors examining the application and workflow layer, rather than assuming that access to a leading general-purpose model alone creates a durable advantage. No investment recommendation or valuation view on either provider was stated.
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Episode Description
a16z’s Seema Amble and Elena Burger sit down with Lio co-founder and CEO Vladimir Keil to ask where AI-native startups have an advantage when incumbent software companies already own the customer, the data, and the system of record. Their answer comes down to the work that happens outside those systems. In procurement, a final price in an ERP can hide hundreds of emails, spreadsheets, supplier conversations, engineering analyses, and decisions across legal, finance, and operations. Vlad explains how Lio uses multi-agent systems to take on more of that end-to-end work, from sourcing and RFQs to negotiation, shipment tracking, and invoices. They also discuss how enterprises learn to trust agents with increasingly consequential decisions, why the last 20% of an internal AI build can require most of the effort, and what happens when both buyers and suppliers have agents working on their behalf. Resources: Follow Vladimir Keil on X: https://x.com/askvladi?lang=en  Follow Vladimir Keil on LinkedIn: https://www.linkedin.com/in/vladimir-keil/ Follow Seema Amble on X: https://x.com/seema_amble  Learn more about Lio: https://www.lio.ai/  Seema Amble’s “Investing in Lio” article: https://a16z.com/announcement/investing-in-lio/ Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
About The a16z Show
The a16z Show

The a16z Show

By Andreessen Horowitz

The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!