
Maintain long exposure to hardware infrastructure leader NVIDIA (NVDA), as aggressive capital spending will drive strong compute demand until industry supply constraints normalize around 2028.
Invest in API routing and developer middleware platforms, which operate as strategic tollbooths capturing transaction volume regardless of which specific AI model wins the market.
While frontier model leaders like OpenAI and Anthropic capture the vast majority of current revenues, prepare for market power and profit margins to shift downstream toward AI application software as model costs fall.
Prioritize software businesses that own proprietary user interfaces and developer workflows, as deep user integration creates a defensible moat and attracts premium acquisition interest from mega-caps like SpaceX and Stripe.

By Andreessen Horowitz
The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!