
Investors should maintain exposure to AI hardware and semiconductor chipmakers, as rising GPU prices and expanding enterprise inference demand continue to benefit leaders supporting the NVIDIA H100.
Allocate capital toward next-generation endpoint security and AI governance providers, as legacy signature-based cybersecurity tools face rapid disruption from autonomous models.
This enterprise security upgrade represents an immediate growth catalyst, with roughly 50% of enterprise software applications projected to become agentic AI systems by the end of the year.
Look for opportunities in multi-model routing and open-source AI hosting infrastructure, which are benefiting as businesses actively diversify away from proprietary providers like OpenAI and Anthropic.
Finally, favor infrastructure platforms supporting flexible open-weight architectures such as Qwen and GLM-5-2, as enterprises prioritize customizable systems to overcome restrictive vendor guardrails.

By Andreessen Horowitz
The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!