
Treat Frontier AI leaders such as OpenAI, Anthropic, and SpaceX as foundational core holdings rather than speculative bets to capture an estimated $30 trillion economic transformation. Over the next decade, target AI's primary physical bottlenecks by investing directly in energy infrastructure, power grid modernization, and high-density data centers. Expand long-term growth allocations into physical-world technologies, focusing on enterprise robotics, autonomous vehicles like Waymo, and AI-enabled healthcare services. Reduce exposure to legacy seat-based SaaS and debt-heavy 2021–2022 vintage private equity software funds, rotating only into AI-native software platforms. In private markets, avoid median venture capital funds with extended holding periods and concentrate capital exclusively in top-tier managers holding concentrated stakes in category winners.

By Andreessen Horowitz
The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!