
Investors should capitalize on the "SaaS-pocalypse" by targeting software companies with deep real-world moats, such as Navan, which remain defensible through complex global supply chains rather than just code. Focus on the shift from software engineering to physical infrastructure by investing in Compute (GPUs) and Energy (Electricity), as these are now the primary bottlenecks for AI growth. Avoid companies that only offer a cheaper UI or "rebuilt" versions of existing software, as AI can easily replicate these models; instead, look for "silver bricks" or niche enterprise workflows that large AI labs ignore. For long-term growth, prioritize firms and startups that centralize control to rapidly enter emerging sectors like Crypto, Bio, and American Dynamism. Monitor regulatory developments closely, as domestic investment in U.S. compute infrastructure is increasingly tied to geopolitical competition with China.

By Andreessen Horowitz
The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!